Serum cystatin C measured by automated immunoassay: A more sensitive marker of changes in GFR than serum creatinine

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Serum cystatin C measured by automated immunoassay: a more sensitive marker of changes in GFR than serum creatinine.

Serum cystatin C has been suggested as a new marker of GFR. For the introduction of this marker into clinical use a rapid and automated method is required. We have developed and validated an assay for serum cystatin C using latex particle-enhanced immunoturbidimetry. Intra- and inter-assay precision were < 3% and < 5% across the assay range. Analytical recovery was 93 +/- 3.8% and no lack of pa...

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Serum cystatin C is a better marker of topotecan clearance than serum creatinine.

PURPOSE To evaluate plasma cystatin level as a covariate to predict topotecan pharmacokinetics. Cystatin C, a member of the cystatin superfamily of cysteine proteinase inhibitors, has been recently proposed as an alternative endogenous marker of glomerular filtration. Renal function is known as a key factor of topotecan clearance. EXPERIMENTAL DESIGN Data were obtained from 59 patients who un...

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SERUM CYSTATIN C AS A NEW MARKER OF GLOMERULAR FILTRATION RATE (GFR)

Cystatin C is a 13 KD basic protein that is a member of the cystatin superfamily of cysteine protease inhibitors. The cystatin C gene seems to be a house keeping gene, which is compatible with a stable production rate of cystatin C by most cells. This protein is freely filtered through the glomerulus and almost completely reabsorbed and catabolized by proximal tubular cells. Because of the...

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Serum cystatin C, determined by a rapid, automated particle-enhanced turbidimetric method, is a better marker than serum creatinine for glomerular filtration rate.

We describe a fully automated particle-enhanced turbidimetric assay for cystatin C in undiluted serum and EDTA-plasma. The throughput is 90 samples per hour and urgent samples can be analyzed in 7 min. The assay range (0.4-14.1 mg/L) covers the concentration range in health and disease. The within- and between-run imprecision is 0.9% and 2.2%, respectively. Analytical recovery of additions of r...

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serum cystatin c as a new marker of glomerular filtration rate (gfr)

cystatin c is a 13 kd basic protein that is a member of the cystatin superfamily of cysteine protease inhibitors. the cystatin c gene seems to be a house keeping gene, which is compatible with a stable production rate of cystatin c by most cells. this protein is freely filtered through the glomerulus and almost completely reabsorbed and catabolized by proximal tubular cells. because of these ch...

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ژورنال

عنوان ژورنال: Kidney International

سال: 1995

ISSN: 0085-2538

DOI: 10.1038/ki.1995.40